With Saturday's 2-1 victory against Schalke 04, Bayer Leverkusen are currently in 4th place in the Bundesliga with 25 points, six points from first place, currently occupied by Borussia Mönchengladbach.
Between both the league championship and cup matches, Kevin Volland is their top scorer with seven goals, followed by Lucas Alario (five), Leon Bailey (four), Kai Havertz (three), Karim Bellarabi (two) and Sven Bender, Moussa Diaby, Paulinho and Charles Aranguiz with one.
The BayArena match will be vital for Leverkusen, as should the Germans emerge victorious and Atletico Madrid fail to beat Lokomotiv Moscow, Die Werkself would qualify for the Champions League Last 16.
In the first game, played on 1 October at Allianz Stadium in Turin, Maurizio Sarri's team easily won 3-0 thanks to goals from Gonzalo Higuain, Federico Bernardeschi and Cristiano Ronaldo. The Bayer side initially started with a dynamic 4-2-3-1, the formation most often used by Peter Bosz, the very same coach who in the 2016/2017 season handed Matthijs de Ligt his debut with the Ajax First Team.